Article
Technical report: exploring the basis of congenital myasthenic syndromes in an undergraduate course, using the model organism, Caenorhabditis elegans.
Invertebrate neuroscience : IN - 1 Nov 2010
Kaas Bonnie, Vaidya Avinash R, Leatherman Amanda, Schleidt Stephanie, Kohn Rebecca Eustance
Abstract excerpt
Mutations affecting acetylcholine receptors have been causally linked to the development of congenital myasthenic syndromes (CMS) in humans resulting from neuromuscular transmission defects. In an undergraduate Molecular Neurobiology course, the molecular basis of CMS was explored through study of a Caenorhabditis elegans model of the disease. The nicotinic acetylcholine receptor (nAChR), located on the...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cholinesterase Inhibitors
- Disease Models, Animal
- Education, Medical, Undergraduate
- Mutation
- Myasthenic Syndromes, Congenital
- Pyridostigmine Bromide
- Receptors, Nicotinic