Article
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans.
Neuron - 1 Apr 1995
Treinin M, Chalfie M
Abstract excerpt
Neurotoxicity through abnormal activation of membrane channels is a potential cause of neurodegenerative disease. Here we show that a gain-of-function mutation, deg.3(u662), leads to the degeneration of a small set of neurons in the nematode C. elegans. The deg.3 gene encodes a nicotinic acetylch...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis
- Gene Expression
- Green Fluorescent Proteins
- Luminescent Proteins
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Nerve Degeneration
- Nicotine
- Phenotype
- Receptors, Cholinergic
- Recombinant Fusion Proteins
- Restriction Mapping