Article
Roles of SIRT1 in the acute and restorative phases following induction of inflammation.
The Journal of biological chemistry - 31 Dec 2010
Zhang Zhiyong, Lowry Stephen F, Guarente Leonard, Haimovich Beatrice
Abstract excerpt
Endotoxin is a potent inducer of systemic inflammatory responses in human and rodents. Here, we show that in vivo endotoxin triggers a rapid and transient decline in ATP concentration in human peripheral blood leukocytes and murine peripheral blood leukocytes and liver, which is associated with a brief increase in expression of the autophagy indicator LC3-II. In both of these tissues, the ATP concentration...
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