Article
Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.
Infection and immunity - 1 Feb 2013
Liao Kuo-Chieh, Mogridge Jeremy
Abstract excerpt
The efficacy of the innate immune system depends on its ability to mount an appropriate response to diverse infections and damaging agents. Key components of this system are pattern recognition receptors that detect pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Nlrp1b is a pattern recognition receptor that forms a caspase-1 activation platform, known as an inflammasome, upon...
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