Article
Mutation of mitochondrial ATP8 gene improves hepatic energy status in a murine model of acute endotoxemic liver failure.
Life sciences - 14 Feb 2011
Eipel Christian, Hildebrandt Anke, Scholz Birte, Schyschka Lilianna, Minor Thomas, Kreikemeyer Bernd, Ibrahim Saleh M, Vollmar Brigitte
Abstract excerpt
AIMS: Mitochondria not only generate and modulate bioenergy but also serve as biosensors for oxidative stress, and eventually become effector organelles for cell viability. Therefore, the implications of mitochondrial (dys)function in the development of multiple organ failure are profound. We investigated whether a mutation in the ATPase subunit-8 gene affects the course of endotoxemic acute liver failure. MAIN...
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