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Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls.

Neurotoxicology - 1 Mar 2018

Colter Breann T, Garber Helen Frances, Fleming Sheila M, Fowler Jocelyn Phillips, Harding Gregory D, Hooven Molly Kromme, Howes Amy Ashworth, Infante Smitha Krishnan, Lang Anna L, MacDougall Melinda Curran, Stegman Melinda, Taylor Kelsey Rae, Curran Christine Perdan

Abstract excerpt

Polychlorinated biphenyls (PCBs) are persistent organic pollutants known to cause adverse health effects and linked to neurological deficits in both human and animal studies. Children born to exposed mothers are at highest risk of learning and memory and motor deficits. We developed a mouse model that mimics human variation in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) to determine if genetic...

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Identifiers

PMID: 29409959
DOI: 10.1016/j.neuro.2018.01.008
PMCID: PMC5857246

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls.PMID 29409959Read ↗

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