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Article

Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity.

Neurotoxicology - 1 Dec 2012

Curran Christine Perdan, Altenhofen Emily, Ashworth Amy, Brown Austin, Kamau-Cheggeh Cellestine, Curran Melinda, Evans Amber, Floyd Rikki, Fowler Jocelyn, Garber Helen, Hays Breann, Kraemer Sarah, Lang Anna, Mynhier Andrea, Samuels Ashton, Strohmaier Carly

Abstract excerpt

Polychlorinated biphenyls (PCBs) are developmental neurotoxicants that produce cognitive and behavioral changes in children exposed during gestation and lactation. Coplanar PCBs bind the aryl hydrocarbon receptor (AHR) and can be sequestered in liver by cytochrome P450 1A2 (CYP1A2). The AHR is a ligand-activated transcription factor which increases expression of the CYP1 family, including CYP1A2. Our previous...

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Source

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Identifiers

PMID: 22935098
DOI: 10.1016/j.neuro.2012.08.005
PMCID: PMC3518762

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity.PMID 22935098Read ↗

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