Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.

doi:10.1007/s00335-017-9728-1

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Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2018

Klinefelter Kelsey, Hooven Molly Kromme, Bates Chloe, Colter Breann T, Dailey Alexandra, Infante Smitha Krishnan, Kania-Korwel Izabela, Lehmler Hans-Joachim, López-Juárez Alejandro, Ludwig Clare Pickering, Curran Christine Perdan

Abstract excerpt

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that remain a human health concern with newly discovered sources of contamination and ongoing bioaccumulation and biomagnification. Children exposed during early brain development are at highest risk of neurological deficits, but highly exposed adults reportedly have an increased risk of Parkinson's disease. Our previous studies found allelic...

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PMID: 29197979
DOI: 10.1007/s00335-017-9728-1
PMCID: PMC6425730

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