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Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2011

Verhofstad Nicole, van Oostrom Conny Th M, Zwart Edwin, Maas Lou M, van Benthem Jan, van Schooten Frederik J, van Steeg Harry, Godschalk Roger W L

Abstract excerpt

Polycyclic aromatic hydrocarbons (PAHs) are mutagenic in somatic cells, whereas it remains unclear whether PAHs induce mutations in male germ cells, subsequently increasing health risks in offspring. Although results from the classical specific locus test are negative or inconclusive, recent studies with environmentally exposed animals suggest that PAHs are mutagenic in sperm cells. Therefore, we studied whether...

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PMID: 20961952
DOI: 10.1093/toxsci/kfq325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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