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Article

The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development.

Immunobiology - 1 Mar 2011

Messler Sabine, Kropp Sonja, Episkopou Vasso, Felici Angelina, Würthner Jan, Lemke Robin, Jerabek-Willemsen Moran, Willecke Regina, Scheu Stefanie, Pfeffer Klaus, Wurthner Jens U

Abstract excerpt

The pleiotropic cytokine transforming growth factor-β (TGF-β) signals through different pathways among which the Smad- and the MAP-Kinase pathways are already well characterized. Both pathways utilize adaptor/chaperone molecules that facilitate or modulate the intracellular signaling events. Two of the proteins shown in vitro to play a role in Smad-dependent signaling are the TGF-β Receptor Associated Protein-1...

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Source

Identifiers

PMID: 20961651
DOI: 10.1016/j.imbio.2010.07.006

Genes

TRAP1
VPS39
TGFBRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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