Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity.

The EMBO journal - 15 Dec 1998

Royet J, Bouwmeester T, Cohen S M

Abstract excerpt

Signaling by Notch family receptors is involved in many cell-fate decisions during development. Several modifiers of Notch activity have been identified, suggesting that regulation of Notch signaling is complex. In a genetic screen for modifiers of Notch activity, we identified a gene encoding a novel WD40-repeat protein. The gene is called Notchless, because loss-of-function mutant alleles dominantly suppress...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cloning, Molecular
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Homology, Amino Acid

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 9857191
DOI: 10.1093/emboj/17.24.7351
PMCID: PMC1171080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity.PMID 9857191Read ↗

Notch signaling: control of cell communication and cell fate.Semantic proximity Read ↗

Notch -- a goldilocks signaling pathway in disease and cancer therapy.Semantic proximity Read ↗

Modulation of wingless signaling by Notch in Drosophila.Semantic proximity Read ↗

Notch signaling in the mammalian central nervous system: insights from mouse mutants.Semantic proximity Read ↗

Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.Semantic proximity Read ↗

Modifiers of notch transcriptional activity identified by genome-wide RNAi.Semantic proximity Read ↗

Functional genomic analysis of the Wnt-wingless signaling pathway.Semantic proximity Read ↗

Notch signaling in human development and disease.Semantic proximity Read ↗

Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes.Semantic proximity Read ↗

Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis.Semantic proximity Read ↗

New alleles of Notch draw a blueprint for multifunctionality.Semantic proximity Read ↗

Functional conservation of Notch1 and Notch2 intracellular domains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.