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Article

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.

Nature - 23 Apr 2009

Mummery-Widmer Jennifer L, Yamazaki Masakazu, Stoeger Thomas, Novatchkova Maria, Bhalerao Sheetal, Chen Doris, Dietzl Georg, Dickson Barry J, Knoblich Juergen A

Abstract excerpt

Genome-wide RNA interference (RNAi) screens have identified near-complete sets of genes involved in cellular processes. However, this methodology has not yet been used to study complex developmental processes in a tissue-specific manner. Here we report the use of a library of Drosophila strains expressing inducible hairpin RNAi constructs to study the Notch signalling pathway during external sensory organ...

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Identifiers

PMID: 19363474
DOI: 10.1038/nature07936
PMCID: PMC2988197

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