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Article

A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells.

The Journal of biological chemistry - 30 Nov 2012

Kim Jeffrey J, Khalid Omar, Vo Sheynie, Sun Ho-hyun, Wong David T W, Kim Yong

Abstract excerpt

The nucleosome remodeling and deacetylation (NuRD) complex is required for modulating the transcription of essential pluripotency genes in ESC self-renewal. MBD3 is considered a key player in the formation of a functional NuRD complex. The recruitment of MBD3 to methylated promoters may require other prerequisite factors. We show that cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for...

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Share to DNA Methylation
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Share to Tumor Suppressor Proteins

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Source

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Identifiers

PMID: 23074223
DOI: 10.1074/jbc.M112.416545
PMCID: PMC3510811

Genes

MBD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells.PMID 23074223Read ↗

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