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Article

A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network.

Developmental cell - 18 May 2010

Saj Abil, Arziman Zeynep, Stempfle Denise, van Belle Werner, Sauder Ursula, Horn Thomas, Dürrenberger Markus, Paro Renato, Boutros Michael, Merdes Gunter

Abstract excerpt

Notch signaling plays a fundamental role in cellular differentiation and has been linked to human diseases, including cancer. We report the use of comprehensive RNAi analyses to dissect Notch regulation and its connections to cellular pathways. A cell-based RNAi screen identified 900 candidate Notch regulators on a genome-wide scale. The subsequent use of a library of transgenic Drosophila expressing RNAi...

Topics

Animals
Drosophila
Drosophila Proteins
Gene Expression Regulation
Genome-Wide Association Study
Humans
Neoplasms
Phenotype
RNA Interference
RNA, Small Interfering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Notch

Signal Transduction

Wings, Animal

Source

Identifiers

PMID: 20493818
DOI: 10.1016/j.devcel.2010.03.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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