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Article

Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.

BMC pulmonary medicine - 11 May 2020

Kabir Saba, Tahir Zarfishan, Mukhtar Nadia, Sohail Muhammad, Saqalein Muhammad, Rehman Abdul

Abstract excerpt

BACKGROUND: Fluoroquinolones (FQs) are potential drugs that inhibit DNA synthesis and are used in the treatment of multidrug-resistant tuberculosis (TB) and short-term anti-TB regimens. In recent years, a high proportion of FQ resistance has been observed in Mycobacterium tuberculosis isolates. The development of FQ resistance in multidrug-resistant TB negatively impacts patient treatment outcome and is a serious...

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Identifiers

PMID: 32393213
DOI: 10.1186/s12890-020-1172-4
PMCID: PMC7216623

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