Article
Functional analysis of DNA gyrase mutant enzymes carrying mutations at position 88 in the A subunit found in clinical strains of Mycobacterium tuberculosis resistant to fluoroquinolones.
Antimicrobial agents and chemotherapy - 1 Dec 2006
Matrat Stéphanie, Veziris Nicolas, Mayer Claudine, Jarlier Vincent, Truffot-Pernot Chantal, Camuset Juliette, Bouvet Elisabeth, Cambau Emmanuelle, Aubry Alexandra
Abstract excerpt
We investigated the enzymatic efficiency and inhibition by quinolones of Mycobacterium tuberculosis DNA gyrases carrying the previously described GyrA G88C mutation and the novel GyrA G88A mutation harbored by two multidrug-resistant clinical strains and reproduced by site-directed mutagenesis. Fluoroquinolone MICs and 50% inhibitory concentrations for both mutants were 2- to 43-fold higher than for the wild...
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