Article
DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Oct 2011
Pantel Alix, Petrella Stéphanie, Matrat Stéphanie, Brossier Florence, Bastian Sylvaine, Reitter Delphine, Jarlier Vincent, Mayer Claudine, Aubry Alexandra
Abstract excerpt
The main mechanism of fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis is mutation in DNA gyrase (GyrA(2)GyrB(2)), especially in gyrA. However, the discovery of unknown mutations in gyrB whose implication in FQ resistance is unclear has become more frequent. We investigated the impact on FQ susceptibility of eight gyrB mutations in M. tuberculosis clinical strains, three of which were previously...
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