Article
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
Antimicrobial agents and chemotherapy - 1 Jan 2006
Aubry Alexandra, Veziris Nicolas, Cambau Emmanuelle, Truffot-Pernot Chantal, Jarlier Vincent, Fisher L Mark
Abstract excerpt
Mutations in the DNA gyrase GyrA2GyrB2 complex are associated with resistance to quinolones in Mycobacterium tuberculosis. As fluoroquinolones are being used increasingly in the treatment of tuberculosis, we characterized several multidrug-resistant clinical isolates of M. tuberculosis carrying mutations in the genes encoding the GyrA or GyrB subunits associated with quinolone resistance or hypersusceptibility....
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