Article
Adenoviral activin a expression prevents intimal hyperplasia in human and murine blood vessels by maintaining the contractile smooth muscle cell phenotype.
Circulation research - 31 May 2002
Engelse Marten A, Lardenoye JanWillem H P, Neele Jolanda M, Grimbergen Jos M, De Vries Margreet R, Lamfers Martine L M, Pannekoek Hans, Quax Paul H A, De Vries Carlie J M
Abstract excerpt
Activin A alters the characteristics of human arterial smooth muscle cells (SMCs) toward a contractile, quiescent phenotype. We hypothesize that activin A may prevent SMC-rich neointimal hyperplasia. Here, we study the effect of adenovirus-mediated expression of activin A on neointima formation in vitro and in vivo. Human saphenous vein organ cultures, in which a neointima is formed spontaneously, were infected...
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