Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activin A Is a Master Regulator of Phenotypic Switch in Adipose Stromal Cells Initiated by Activated Immune Cell-Secreted Interleukin-1β.

Stem cells and development - 1 Aug 2024

Manohar-Sindhu Sahana, Merfeld-Clauss Stephanie, March Keith L, Traktuev Dmitry O

Abstract excerpt

Prolonged tissue ischemia and inflammation lead to organ deterioration and are often accompanied by microvasculature rarefaction, fibrosis, and elevated systemic Activin A (ActA), the level of which frequently correlates with disease severity. Mesenchymal stromal cells are prevalent in the perivascular niche and are likely involved in tissue homeostasis and pathology. This study investigated the effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activins
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Connective Tissue Growth Factor

Share to Interleukin-1beta

Share to Mesenchymal Stem Cells

Share to Myocytes, Smooth Muscle

Share to Myofibroblasts

Source

Identifiers

PMID: 38877807
DOI: 10.1089/scd.2024.0092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activin A Is a Master Regulator of Phenotypic Switch in Adipose Stromal Cells Initiated by Activated Immune Cell-Secreted Interleukin-1β.PMID 38877807Read ↗

Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β.Semantic proximity Read ↗

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2.Semantic proximity Read ↗

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β.Semantic proximity Read ↗

Targeting Macrophage Crosstalk to PASMC by Blunting Inflammatory Phenotype Via SerpinB1 Protects Against Hypoxia-Induced Pulmonary Hypertension.Semantic proximity Read ↗

Paracrine signalling from monocytes enables desirable extracellular matrix accumulation and temporally appropriate phenotype of vascular smooth muscle cell-like cells derived from adipose stromal cells.Semantic proximity Read ↗

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts.Semantic proximity Read ↗

TGFbeta family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages.Semantic proximity Read ↗

Expansion of the human adipose-derived stromal vascular cell fraction yields a population of smooth muscle-like cells with markedly distinct phenotypic and functional properties relative to mesenchymal stem cells.Semantic proximity Read ↗

Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue FibrosisSemantic proximity Read ↗

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophySemantic proximity Read ↗

The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases.Semantic proximity Read ↗

Differentiation of adult stem cells into smooth muscle for vascular tissue engineering.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.