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Article

Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification

12 Aug 2021

Abstract excerpt

A current hypothesis is that transforming growth factor-β signaling ligands, such as activin-A and myostatin, play a role in vascular damage in atherosclerosis and chronic kidney disease (CKD). Myostatin and activin-A bind with different affinity the activin receptors (type I or II), activating distinct intracellular signaling pathways and finally leading to modulation of gene expression. Myostatin and activin-A...

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PMID: 34440838
DOI: 10.3390/cells10082070

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