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Article

Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.

European journal of human genetics : EJHG - 1 Oct 2014

Malzahn Dörthe, Müller-Nurasyid Martina, Heid Iris M, Wichmann H-Erich, Bickeböller Heike

Abstract excerpt

Among the single-nucleotide polymorphisms (SNPs) previously reported to be associated with body mass index (BMI) and obesity, we focus on a common risk variant rs7566605 upstream of the insulin-induced gene 2 (INSIG2) gene and a rare protective variant rs2229616 on the melanocortin-4 receptor (MC4R) gene. INSIG2 is involved in adipogenesis and MC4R effects hormonal appetite control in response to the amount of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24518831
DOI: 10.1038/ejhg.2014.3
PMCID: PMC4169541

Genes

INSIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.PMID 24518831Read ↗

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.Semantic proximity Read ↗

Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.Semantic proximity Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

Comment on "A common genetic variant is associated with adult and childhood obesity".Semantic proximity Read ↗

Genotype-covariate interaction effects and the heritability of adult body mass index.Semantic proximity Read ↗

A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.Semantic proximity Read ↗

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).Semantic proximity Read ↗

A common polymorphism is associated with body mass index in Uyghur population.Semantic proximity Read ↗

An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.Semantic proximity Read ↗

Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth.Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.Semantic proximity Read ↗

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