Article
INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample.
Folia biologica - 1 Jan 2010
Hubácek J A, Kuthanová L, Bohuslavová R, Adámková V, Lánská V, Meitinger T, Pfeufer A
Abstract excerpt
Heritability studies have estimated the genetically attributable part of body mass index variance to be in the range of 30-70 %. Rs7566650 (G>C) single-nucleotide polymorphism (SNP) near the promoter of the INSIG2 gene has been identified as associated with body mass index. The gene product of INSIG2 is involved in regulation of fatty acid and cholesterol synthesis. In order to replicate this association we have...
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