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Article

In vitro screening for population variability in chemical toxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Feb 2011

O'Shea Shannon H, Schwarz John, Kosyk Oksana, Ross Pamela K, Ha Min Jin, Wright Fred A, Rusyn Ivan

Abstract excerpt

Immortalized human lymphoblastoid cell lines have been used to demonstrate that it is possible to use an in vitro model system to identify genetic factors that affect responses to xenobiotics. To extend the application of such studies to investigative toxicology by assessing interindividual and population-wide variability and heritability of chemical-induced toxicity phenotypes, we have used cell lines from the...

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Identifiers

PMID: 20952501
DOI: 10.1093/toxsci/kfq322
PMCID: PMC3023564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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