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Article

Prediction of human population responses to toxic compounds by a collaborative competition.

Nature biotechnology - 1 Sept 2015

Eduati Federica, Mangravite Lara M, Wang Tao, Tang Hao, Bare J Christopher, Huang Ruili, Norman Thea, Kellen Mike, Menden Michael P, Yang Jichen, Zhan Xiaowei, Zhong Rui, Xiao Guanghua, Xia Menghang, Abdo Nour, Kosyk Oksana, Friend Stephen, Dearry Allen, Simeonov Anton, Tice Raymond R, Rusyn Ivan, Wright Fred A, Stolovitzky Gustavo, Xie Yang, Saez-Rodriguez Julio

Abstract excerpt

The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here, we report the results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations. We measured the cytotoxicity of 156 compounds in 884 lymphoblastoid cell lines for...

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Identifiers

PMID: 26258538
DOI: 10.1038/nbt.3299
PMCID: PMC4568441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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