Article
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.
Nature biotechnology - 1 Jun 2014
Kleinstreuer Nicole C, Yang Jian, Berg Ellen L, Knudsen Thomas B, Richard Ann M, Martin Matthew T, Reif David M, Judson Richard S, Polokoff Mark, Dix David J, Kavlock Robert J, Houck Keith A
Abstract excerpt
Addressing the safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals in need of assessment and the challenges of species extrapolation require the development of alternative approaches. Our approach, the US Environmental Protection Agency's ToxCast program, utilizes a large suite of in vitro and model organism assays to...
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