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Article

A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2020

Blanchette Alexander D, Burnett Sarah D, Grimm Fabian A, Rusyn Ivan, Chiu Weihsueh A

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes are an established model for testing potential chemical hazards. Interindividual variability in toxicodynamic sensitivity has also been demonstrated in vitro; however, quantitative characterization of the population-wide variability has not been fully explored. We sought to develop a method to address this gap by combining a population-based...

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Identifiers

PMID: 33078833
DOI: 10.1093/toxsci/kfaa151
PMCID: PMC7751158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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