Article
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.
Environmental health perspectives - 1 May 2015
Abdo Nour, Xia Menghang, Brown Chad C, Kosyk Oksana, Huang Ruili, Sakamuru Srilatha, Zhou Yi-Hui, Jack John R, Gallins Paul, Xia Kai, Li Yun, Chiu Weihsueh A, Motsinger-Reif Alison A, Austin Christopher P, Tice Raymond R, Rusyn Ivan, Wright Fred A
Abstract excerpt
BACKGROUND: Understanding of human variation in toxicity to environmental chemicals remains limited, so human health risk assessments still largely rely on a generic 10-fold factor (10½ each for toxicokinetics and toxicodynamics) to account for sensitive individuals or subpopulations. OBJECTIVES:...
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