Article

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility

2025-12-19

Abstract excerpt

Inter-individual and population variability in susceptibility to chemical exposures confounds determination of threshold exposure levels to protect the most vulnerable. Current risk assessment frameworks, in the absence of empiric chemical-specific data, generally recommend default or probabilistic adjustment factors to account for such variability. We present an experimental approach to incorporate common genetic...

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Identifiers and source

Literature Corpus work: 22e94448-1b52-5d07-b065-500cde6ddf16
DOI: 10.64898/2025.12.16.694775

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