Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The past, present, and future of CRM1/XPO1 inhibitors

1 Feb 2019

Abstract excerpt

Therapies targeted at inhibiting nucleo-cytoplasmic transport have found broad applications in the field of oncology. Chromosome region maintenance 1 (CRM1), better known as exportin 1 (XPO1), is the protein transporter responsible for the nucleo-cytoplasmic shuttling of most of the tumor suppressor proteins (TSP) and growth regulatory factors. XPO1 is also upregulated in many malignancies and associated with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30976603
DOI: 10.21037/sci.2019.02.03

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The past, present, and future of CRM1/XPO1 inhibitorsPMID 30976603Read ↗

Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agentsSemantic proximity Read ↗

SINE (selective inhibitor of nuclear export) – translational science in a new class of anti-cancer agentsSemantic proximity Read ↗

Targeting XPO1-Dependent Nuclear Export in Cancer.Semantic proximity Read ↗

Inhibiting cancer cell hallmark features through nuclear export inhibitionSemantic proximity Read ↗

Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its InhibitorSemantic proximity Read ↗

Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic ShuttlingSemantic proximity Read ↗

Targeting nuclear import and export in hematological malignanciesSemantic proximity Read ↗

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemiaSemantic proximity Read ↗

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal TransitionSemantic proximity Read ↗

Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma.Semantic proximity Read ↗

Small Molecule Inhibitors of CRM1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.