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Article

Targeting XPO1-Dependent Nuclear Export in Cancer.

Biochemistry. Biokhimiia - 1 Jan 2022

Kim Ekaterina, Mordovkina Daria A, Sorokin Alexey

Abstract excerpt

Nucleocytoplasmic transport of macromolecules is tightly regulated in eukaryotic cells. XPO1 is a transport factor responsible for the nuclear export of several hundred protein and RNA substrates. Elevated levels of XPO1 and recurrent mutations have been reported in multiple cancers and linked to advanced disease stage and poor survival. In recent years, several novel small-molecule inhibitors of XPO1 were...

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Active Transport, Cell Nucleus
Karyopherins
Mutation
Neoplasms
Receptors, Cytoplasmic and Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35501995
DOI: 10.1134/S0006297922140140

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