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Article

Alterations in local stability and dynamics of A4V SOD1 in the presence of trifluoroethanol.

Biopolymers - 1 Mar 2018

Kumar Vijay, Prakash Amresh, Lynn Andrew M

Abstract excerpt

Alterations in the local dynamics of Cu/Zn Superoxide dismutase (SOD1) due to mutations affect the protein folding, stability, and function leading to misfolding and aggregation seen in amyotrophic lateral sclerosis (ALS). Here, we study the structure and dynamics of the most devastating ALS mutation, A4V SOD1 in aqueous trifluoroethanol (TFE) through experiments and simulation. Far-UV circular dichroism (CD)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29369331
DOI: 10.1002/bip.23102

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SOD1

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