Article

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

2021-07-26

Abstract excerpt

The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, Brachydactyly B and metastatic diseases. The domain(s) and mechanisms required for ROR2 function, however, remain unclear. We solved the crystal structure of the extracellular cysteine-rich (CRD) and Kringle (Kr) domains of ROR2 and found tha...

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Literature Corpus work: 0a67e013-6c46-582f-8079-3c02fa180480
DOI: 10.1101/2021.07.26.453829

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