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Article

The role of OATP1B1 and BCRP in pharmacokinetics and DDI of novel statins.

Cardiovascular therapeutics - 1 Oct 2012

Hua Wen Jin, Hua Wei Xiao, Fang Hu Jin

Abstract excerpt

The aim of this review is to provide useful information not only for studying the effect of OATP1B1 and/or BCRP gene mutation on pharmacokinetics of novle statins of pitavastatin and rosuvastatin but also for studying drug-drug interactions (DDI) between the novle statins and other substrates of OATP1B1 and/or BCRP. Intra- and inter-ethnic differences in pharmacokinetic profiles of clinically relevant drugs are...

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PMID: 21884024
DOI: 10.1111/j.1755-5922.2011.00290.x

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