Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants.

Pharmacogenetics and genomics - 1 Aug 2007

Ho Richard H, Choi Leena, Lee Wooin, Mayo Gail, Schwarz Ute I, Tirona Rommel G, Bailey David G, Stein C Michael, Kim Richard B

Abstract excerpt

OBJECTIVE: Our aims were to evaluate the effects of polymorphisms in the hepatic drug uptake transporter organic anion transporting polypeptide 1B1 (OATP1B1, SLCO1B1) and efflux transporters multidrug resistance-associated protein 2 (MRP2, ABCC2), bile salt export pump (BSEP, ABCB11), and breast cancer-related protein (BCRP, ABCG2) on single-dose pravastatin pharmacokinetics in healthy European- and...

Topics

Join the communities discussing this publication.

Area Under Curve
Bilirubin
Black or African American
Gene Frequency
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multidrug Resistance-Associated Protein 2

Source

Open in PubMed Open full text

Identifiers

PMID: 17622941
DOI: 10.1097/FPC.0b013e3280ef698f
PMCID: PMC4063287

Genes

ABCB11
ABCC2
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants.PMID 17622941Read ↗

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.Semantic proximity Read ↗

Effects of single nucleotide polymorphisms and haplotypes of the SLCO1B1 gene on the pharmacokinetic profile of atorvastatin in healthy Macedonian volunteers.Semantic proximity Read ↗

[Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].Semantic proximity Read ↗

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).Semantic proximity Read ↗

An update on efflux and uptake transporters as determinants of statin response.Semantic proximity Read ↗

Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1).Semantic proximity Read ↗

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin.Semantic proximity Read ↗

Pharmacogenetics of membrane transporters: a review of current approaches.Semantic proximity Read ↗

Effects of two functionally important SLCO1B1 gene polymorphisms on pharmacokinetics of atorvastatin.Semantic proximity Read ↗

Impact of OATP transporters on pharmacokinetics.Semantic proximity Read ↗

Identification of Genetic Variants Associated with Pravastatin and Pitavastatin Pharmacokinetics.Semantic proximity Read ↗

Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.