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Article

The effect of SLCO1B115 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B115.

Pharmacogenetics and genomics - 1 May 2008

Deng Jian Wei, Song Im-Sook, Shin Ho Jung, Yeo Chang-Woo, Cho Doo-Yeoun, Shon Ji-Hong, Shin Jae-Gook

Abstract excerpt

OBJECTIVE: This study was addressed to understand the underlying mechanism of the substrate-dependent effect of genetic variation in SLCO1B1, which encodes OATP1B1 (organic anion transporting polypeptide) transporter, on the disposition of two OATP1B1 substrates, pravastatin and pitavastatin, in...

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Source

Identifiers

PMID: 18408565
DOI: 10.1097/FPC.0b013e3282fb02a3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18408565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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