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Article

Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Oct 2010

Gao Ming, Jin Yu, Yang Kechun, Zhang Die, Lukas Ronald J, Wu Jie

Abstract excerpt

Systemic exposure to nicotine induces glutamatergic synaptic plasticity on dopamine (DA) neurons in the ventral tegmental area (VTA), but mechanisms are largely unknown. Here, we report that single, systemic exposure in rats to nicotine (0.17 mg/kg free base) increases the ratio of DA neuronal currents mediated by AMPA relative to NMDA receptors (AMPA/NMDA ratio) assessed 24 h later, based on slice-patch...

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Source

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Identifiers

PMID: 20943922
DOI: 10.1523/JNEUROSCI.1943-10.2010
PMCID: PMC2995497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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