Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity.

doi:10.1186/1471-2350-11-147

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Article

Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity.

BMC medical genetics - 13 Oct 2010

Ramanujam Ryan, Zhao Yaofeng, Pirskanen Ritva, Hammarström Lennart

Abstract excerpt

BACKGROUND: The major histocompatibility complex class II transactivator (CIITA) regulates MHC class II gene expression. A promoter SNP -168A→G (rs3087456) has previously been shown to be associated with susceptibility to several immune mediated disorders, including rheumatoid arthritis (RA), multiple sclerosis (MS) and myocardial infarction (MI). Myasthenia gravis (MG) is an autoimmune disorder which has...

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Identifiers

PMID: 20942939
DOI: 10.1186/1471-2350-11-147
PMCID: PMC2970590

Genes

CIITA
PTPN22
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity.PMID 20942939Read ↗

The MHC2TA-168A/G and +1614G/C polymorphisms and risk for multiple sclerosis or chronic inflammatory arthropathies.Semantic proximity Read ↗

MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients.Semantic proximity Read ↗

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The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association.Semantic proximity Read ↗

Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups.Semantic proximity Read ↗

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