Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MHC2TA-168A/G and +1614G/C polymorphisms and risk for multiple sclerosis or chronic inflammatory arthropathies.

Tissue antigens - 1 Sept 2007

O'Doherty C, Hawkins S, Rooney M, Vandenbroeck K

Abstract excerpt

The -168A-G polymorphism has been shown to influence transcription of the MHC2TA gene and has been implicated in several inflammatory/autoimmune disorders. Attempts to reproduce these findings have been inconclusive. We investigated the role of this promoter single nucleotide polymorphism (SNP) in 440 multiple sclerosis (MS), 293 rheumatoid arthritis (RA), 74 juvenile idiopathic arthritis (JIA) patients and 316...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Chronic Disease
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Sclerosis

Share to Nuclear Proteins

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Trans-Activators

Source

Identifiers

PMID: 17661914
DOI: 10.1111/j.1399-0039.2007.00876.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MHC2TA-168A/G and +1614G/C polymorphisms and risk for multiple sclerosis or chronic inflammatory arthropathies.PMID 17661914Read ↗

The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association.Semantic proximity Read ↗

Role of the MHC2TA gene in autoimmune diseases.Semantic proximity Read ↗

MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients.Semantic proximity Read ↗

Investigation of the MHC2TA gene, associated with rheumatoid arthritis in a Swedish population, in a UK rheumatoid arthritis cohort.Semantic proximity Read ↗

The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients.Semantic proximity Read ↗

Association between the functional MHC2TA -168 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

IL7RA polymorphisms and chronic inflammatory arthropathies.Semantic proximity Read ↗

MHC2TA and FCRL3 genes are not associated with rheumatoid arthritis in Mexican patients.Semantic proximity Read ↗

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.Semantic proximity Read ↗

Lack of association of the CIITA -168A→G promoter SNP with myasthenia gravis and its role in autoimmunity.Semantic proximity Read ↗

Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.Semantic proximity Read ↗

Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.