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Article

Identification of SOX9 Interaction Sites in the Genome of Chondrocytes

9 Apr 2010

Abstract excerpt

BACKGROUND: Our previous work has provided strong evidence that the transcription factor SOX9 is completely needed for chondrogenic differentiation and cartilage formation acting as a "master switch" in this differentiation. Heterozygous mutations in SOX9 cause campomelic dysplasia, a severe skeletal dysmorphology syndrome in humans characterized by a generalized hypoplasia of endochondral bones. To obtain...

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PMID: 20404928
DOI: 10.1371/journal.pone.0010113

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Related research

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Research trail→

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Identification of SOX9 Interaction Sites in the Genome of ChondrocytesPMID 20404928Read ↗

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian ChondrocyteSemantic proximity Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasiaSemantic proximity Read ↗

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.Semantic proximity Read ↗

Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificitySemantic proximity Read ↗

Chondrogenic Enhancer Landscape of Limb and Axial Skeleton DevelopmentSemantic proximity Read ↗

Identification of novel craniofacial regulatory domains located far upstream of SOX9 and disrupted in Pierre Robin sequence.Semantic proximity Read ↗

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template.Semantic proximity Read ↗

Long-range regulation at the <i>SOX9</i> locus in development and disease: Figure 1Semantic proximity Read ↗

SOX9 in organogenesis: shared and unique transcriptional functions.Semantic proximity Read ↗

SOX9 in cartilage development and diseaseSemantic proximity Read ↗

Epigenetic control of SOX9 gene by the histone acetyltransferase P300 in human Sertoli cellsSemantic proximity Read ↗

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