Zinc‐finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair

Abstract excerpt

OBJECTIVE: Human mesenchymal stem cells (hMSCs) represent one of the most promising stem cell therapies for traumatic injury and age-related degenerative diseases involving cartilage. However, few genetic factors regulating chondrogenesis of MSCs have been identified. One study showed that zinc-finger protein 145 (ZNF145), a transcription factor, was up-regulated during 3-lineage differentiation of hMSCs. The...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Developmental Biology and Gene Regulation
• Share to Mesenchymal stem cell research
• Share to Osteoarthritis Treatment and Mechanisms