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Article

SOX9-dependent and -independent Transcriptional Regulation of Human Cartilage Link Protein

29 Sept 2004

Abstract excerpt

Cartilage link protein is a key component of the cartilage extracellular matrix. The transcriptional regulation of the gene encoding cartilage link protein (CRTL1) is largely unknown, however. Here, we investigated the regulation of CRTL1 by SOX9, a key regulator of cartilage matrix genes and chondrogenesis. Knockdown of SOX9 resulted in decreased CRTL1 expression. SOX9 induced CRTL1 expression effectively in...

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PMID: 15456769
DOI: 10.1074/jbc.m406786200

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