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Transcriptional coactivator PGC-1α regulates chondrogenesis via association with Sox9

7 Feb 2005

Abstract excerpt

Chondrogenesis is a multistep pathway in which multipotential mesenchymal stem cells (MSC) differentiate into chondrocytes. The transcription factor Sox9 (SRY-related high mobility group-Box gene 9) regulates chondrocyte differentiation and cartilage-specific expression of genes, such as Col2a1 (collagen type II alpha1). However, Sox9 expression is detected not only in chondrogenic tissue but also in...

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PMID: 15699338
DOI: 10.1073/pnas.0407510102

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