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Article

Feedback control of glucocorticoid production is established during fetal development.

Molecular medicine (Cambridge, Mass.) - 1 Nov 1996

Reichardt H M, Schütz G

Abstract excerpt

BACKGROUND: Glucocorticoids are involved in the regulation of metabolic, immunological, and developmental processes. Their synthesis is tightly controlled by feedback regulation through the hypothalamus-pituitary-adrenal (HPA) axis, allowing the organism to respond to stress in an adequate manner and to adapt to new situations. Disturbance of these regulatory mechanisms leads to major human diseases. By...

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PMID: 8972488
PMCID: PMC2230142

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