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Article

An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.

The Journal of biological chemistry - 11 Jan 2008

Romney S Joshua, Thacker Colin, Leibold Elizabeth A

Abstract excerpt

Ferritin is a ubiquitous protein that sequesters iron and protects cells from iron toxicity. Caenorhabditis elegans express two ferritins, FTN-1 and FTN-2, which are transcriptionally regulated by iron. To identify the cis-acting sequences and proteins required for iron-dependent regulation of ftn-1 and ftn-2 expression, we generated transcriptional GFP reporters corresponding to 5 '-upstream sequences of the...

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PMID: 18024960
DOI: 10.1074/jbc.M707043200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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