Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic identification of gene activities promoting hypoxic death.

Genetics - 1 Feb 2009

Mabon Meghann E, Mao Xianrong, Jiao York, Scott Barbara A, Crowder C Michael

Abstract excerpt

The sensitivity of an organism to hypoxic injury varies widely across species and among cell types. However, a systematic description of the determinants of metazoan hypoxic sensitivity is lacking. Toward this end, we screened a whole-genome RNAi library for genes that promote hypoxic sensitivity in Caenorhabditis elegans. RNAi knockdown of 198 genes conferred an invariant hypoxia-resistant phenotype (Hyp-r)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Cell Death
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genes, Helminth

Share to RNA Interference

Share to RNA, Small Interfering

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 19047414
DOI: 10.1534/genetics.108.097188
PMCID: PMC2644942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic identification of gene activities promoting hypoxic death.PMID 19047414Read ↗

Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Genetic analysis of hypoxia signaling and response in C elegans.Semantic proximity Read ↗

Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway.Semantic proximity Read ↗

Transcriptional landscape of a hypoxia response identifies cell-specific pathways for adaptationSemantic proximity Read ↗

A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans.Semantic proximity Read ↗

A Hypoxia Sensitive to Hypoxia Resistant Transformation in Long-Lived Germline MutantsSemantic proximity Read ↗

Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia.Semantic proximity Read ↗

Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.Semantic proximity Read ↗

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Experimental selection for Drosophila survival in extremely low O(2) environment.Semantic proximity Read ↗

Whole-body gene expression atlas of an adult metazoanSemantic proximity Read ↗

A Novel <i>Caenorhabditis elegans</i> Gene Network Uncovers Mechanisms of Mitochondrial MaintenanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.