Article
Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans.
PLoS genetics - 1 Apr 2016
Mann Frederick G, Van Nostrand Eric L, Friedland Ari E, Liu Xiao, Kim Stuart K
Abstract excerpt
To understand the molecular processes underlying aging, we screened modENCODE ChIP-seq data to identify transcription factors that bind to age-regulated genes in C. elegans. The most significant hit was the GATA transcription factor encoded by elt-2, which is responsible for inducing expression of intestinal genes during embryogenesis. Expression of ELT-2 decreases during aging, beginning in middle age. We...
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