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Article

Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.

The Journal of biological chemistry - 17 Dec 2010

Lee Hye Jeong, Joo Myungsoo, Abdolrasulnia Rasul, Young David G, Choi Inyeong, Ware Lorraine B, Blackwell Timothy S, Christman Brian W

Abstract excerpt

Peptidylarginine deiminases (PADs) are enzymes that convert arginine to citrulline in proteins. In this study, we examined PAD-mediated citrullination and its effect on pro-inflammatory activity in the macrophage cell line RAW 264.7. Citrullination of 45-65-kDa proteins was induced when cells wer...

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Identifiers

PMID: 20937835
DOI: 10.1074/jbc.M110.170290
PMCID: PMC3000946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20937835-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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