Article
Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice.
Biochimie - 1 Feb 2013
van Beers Joyce J B C, Zendman Albert J W, Raijmakers Reinout, Stammen-Vogelzangs Judith, Pruijn Ger J M
Abstract excerpt
Citrullination, the conversion of peptidylarginine to peptidylcitrulline is catalyzed by peptidylarginine deiminases (PAD). The expression of PAD isoforms displays great variation among different tissues as demonstrated by PAD mRNA analyses. Here we have analyzed the differential expression of PAD2, PAD4 and PAD6 in mouse tissues at the protein level and by enzymatic activity assays using PAD2 and PAD4 knock-out...
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