Article

Donor-derived mitochondrial DNA variant peptides elicit allo-specific immune response in transplant patients

2020-06-05

Abstract excerpt

In stem cell transplant, mitochondrial DNA (mtDNA) nonsynonymous single nucleotide variants (SNVs) between donor and recipient (D-R) trigger alloimmune responses and transplant rejection. Whether similar alloimmune responses occurs in solid-organ transplantation remains unknown, particularly with the presence of human leukocyte antigen mismatches. This study characterized mtDNA SNVs between D-R of 163 human lung t...

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Literature Corpus work: abcd5beb-49b4-521e-b23a-9763bcbebde2
DOI: 10.1101/2020.06.04.134965

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